Detection of circulating tumor cells in advanced head and neck cancer using the CellSearch system.
Head Neck
; 34(10): 1440-4, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-22076949
ABSTRACT
BACKGROUND:
Early detection of circulating tumor cells (CTCs) offers the possibility of improved outcome for patients with head and neck squamous cell cancer (HNSCC).METHODS:
Patients with advanced-stage HNSCC (stage III/IV) were tested for CTCs using the CellSearch system (a registered trade name), which has been approved by the U.S. Food and Drug Administration (FDA) for monitoring CTCs in other cancers.RESULTS:
CTCs were detected in 6 of 15 patients with advanced-stage HNSCC (range, 1-2 cells/7.5 mL of blood). CTCs were significantly associated with patients with lung nodules >1 cm (p = .04). There was also a suggestion of improved survival in the CTC-negative versus the CTC-positive patients (p = .11).CONCLUSIONS:
CTCs can be successfully isolated in patients with advanced-stage HNSCC using the CellSearch system. CTC detection may be important for prognosis, evaluating treatment outcome, and for determining efficacy of adjuvant treatments.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Escamosas
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Detecção Precoce de Câncer
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Neoplasias de Cabeça e Pescoço
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Neoplasias Pulmonares
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Células Neoplásicas Circulantes
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Recidiva Local de Neoplasia
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article