Fascin promotes the motility and invasiveness of pancreatic cancer cells.
World J Gastroenterol
; 17(40): 4470-8, 2011 Oct 28.
Article
em En
| MEDLINE
| ID: mdl-22110277
ABSTRACT
AIM:
To explore the role of actin-bundling protein, fascin during the progression of pancreatic cancer.METHODS:
The plasmid expressing human fascin-1 was stably transfected into the pancreatic cancer cell line MIA PaCa-2. The proliferation, cell cycle, motility, scattering, invasiveness and organization of the actin filament system in fascin-transfected MIA PaCa-2 cells and control non-transfected cells were determined.RESULTS:
Heterogeneous overexpression of fascin markedly enhanced the motility, scattering, and invasiveness of MIA PaCa-2 cells. However, overexpression of fascin had minimal effect on MIA PaCa-2 cell proliferation and cell cycle. In addition, cell morphology and organization of the actin filament system were distinctly altered in fascin overexpressed cells. When transplanted into BALB/c-nu mice, fascin-transfected pancreatic cancer cells developed solid tumors at a slightly slower rate, but these tumors displayed more aggressive behavior in comparison with control tumors.CONCLUSION:
Fascin promotes pancreatic cancer cell migration, invasion and scattering, thus contributes to the aggressive behavior of pancreatic cancer cells.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Proteínas de Transporte
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Movimento Celular
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Proteínas dos Microfilamentos
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article