Synthetic cyclohexenyl chalcone natural products possess cytotoxic activities against prostate cancer cells and inhibit cysteine cathepsins in vitro.
Biochem Biophys Res Commun
; 416(3-4): 397-402, 2011 Dec 16.
Article
em En
| MEDLINE
| ID: mdl-22120630
ABSTRACT
A number of cyclohexenyl chalcone Diels-Alder natural products possess promising biological properties including strong cytotoxicity in various human cancer cells. Herein, we show that natural products in this class including panduratin A and nicolaioidesin C inhibit cysteine cathepsins as indicated by protease profiling assays and cell-free cathepsin L enzyme assays. Owing to the critical roles of cathepsins in the biology of human tumor progression, invasion, and metastasis, these findings should pave the way for development of novel antitumor agents for use in clinical settings.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
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Produtos Biológicos
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Catepsinas
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Inibidores de Cisteína Proteinase
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Chalcona
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Cicloexanos
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Antineoplásicos
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article