Trichomegaly and other external eye side effects associated with epidermal growth factor.
Cutan Ocul Toxicol
; 31(3): 195-7, 2012 Sep.
Article
em En
| MEDLINE
| ID: mdl-22122121
ABSTRACT
CONTEXT/OBJECTIVE:
To report an association between epithelial growth factor receptor (EGFR) inhibitors and ocular side effects. MATERIALS ANDMETHODS:
Collection of spontaneous reports at the National Registry of Drug-Induced Ocular Side Effects (Casey Eye Institute, Portland, Oregon) in conjunction with a literature review of EGFR inhibitors associated with ocular adverse drug reactions (ADR).RESULTS:
EGFR inhibitors are associated with conjunctivitis, meibomitis, dry eyes, periocular skin changes and trichomegaly. EGFR inhibitors may also cause superficial punctate corneal changes and corneal erosions.DISCUSSION:
This is the first overview of all known ocular side effects associated with the use of marketed EGFR inhibitors. This is also the first effort for this class of drugs using the World Health Organization Classification as to causality.CONCLUSION:
Ophthalmologists should be aware of possible adverse ocular side effects from EGFR inhibitors and treat based on the type of ADR encountered. All ocular side effects noted are fully reversible upon discontinuation of the drug.
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Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Epidérmico
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Olho
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Doenças do Cabelo
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article