Koetjapic acid, a natural triterpenoid, induces apoptosis in colon cancer cells.
Oncol Rep
; 27(3): 727-33, 2012 Mar.
Article
em En
| MEDLINE
| ID: mdl-22134768
ABSTRACT
Deregulated cell signaling pathways result in cancer development. More than one signal transduction pathway is involved in colorectal cancer pathogenesis and progression. Koetjapic acid (KA) is a naturally occurring seco-A-ring oleanene triterpene isolated from the Sandoricum koetjape stem bark. We report the cellular and molecular mechanisms of anticancer activity of KA towards human colorectal cancer. The results showed that KA induces apoptosis in HCT 116 colorectal carcinoma cells by inducing the activation of extrinsic and intrinsic caspases. We confirmed that KA-induced apoptosis was mediated by DNA fragmentation, nuclear condensation and disruption in the mitochondrial membrane potential. Further studies on the effect of KA on cancer pathways show that the compound causes down-regulation of Wnt, HIF-1α, MAP/ERK/JNK and Myc/Max signaling pathways and up-regulates the NF-κB signaling pathway. The result of this study highlights the anticancer potential of KA against colorectal cancer.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
/
Neoplasias Colorretais
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Apoptose
/
Meliaceae
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Antineoplásicos Fitogênicos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article