Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitors.
Bioorg Med Chem Lett
; 22(1): 747-52, 2012 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-22137342
The serine/threonine specific protein kinase B-Raf is part of the MAPK pathway and is an interesting oncology target. We have identified thieno[2,3-d]pyrimidines as a core scaffold of small molecule B-Raf inhibitors. The SAR of analogs in this series will be described.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
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Química Farmacêutica
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Proteínas Proto-Oncogênicas B-raf
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Inibidores de Proteínas Quinases
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article