Carboxymethyl tamarind kernel polysaccharide nanoparticles for ophthalmic drug delivery.
Int J Biol Macromol
; 50(3): 833-9, 2012 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-22138451
ABSTRACT
Tropicamide-loaded carboxymethyl tamarind kernel polysaccharide (CMTKP) nanoparticles were prepared and evaluated for ocular delivery. Preparation of ionotropically gelled CMTKP nanoparticles was optimized employing three-levels, two-factor central composite design. Concentration of polymer and crosslinker had significant synergistic effect on particle size and % encapsulation efficiency. The optimal calculated parameters were concentrations of CMTKP 0.10% (w/v) and calcium chloride 0.11% (w/v). The optimized tropicamide-loaded CMTKP formulation showed ex vivo corneal permeation of tropicamide across isolated goat cornea comparable to its aqueous solution. Further, the mucoadhesive and non-irritant nature of CMTKP nanoparticles indicate their suitability as ocular delivery system.
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Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
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Portadores de Fármacos
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Córnea
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Tamarindus
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Nanopartículas
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article