Global histone H3K27 methylation levels are different in localized and metastatic prostate cancer.
Cancer Invest
; 30(2): 92-7, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-22149091
ABSTRACT
Global histone modification patterns have been shown to be a predictive factor of recurrence in various cancers. We analyzed global histone-3-lysine-27 (H3K27) methylation in prostate cancer (PCA) tissues. H3K27 mono-, di-, and tri-methylation patterns were different in nonmalignant prostate tissue, localized PCA, metastatic PCA, and castration-resistant PCA. H3K27 mono-methylation was correlated with pT-stage, capsular penetration, seminal vesicle infiltration, and Gleason score in localized PCA and may therefore indicate adverse prognosis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Histonas
/
Recidiva Local de Neoplasia
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article