AG490: an inhibitor of hepcidin expression in vivo.
World J Gastroenterol
; 17(45): 5032-4, 2011 Dec 07.
Article
em En
| MEDLINE
| ID: mdl-22174555
ABSTRACT
A liver-produced hormone, hepcidin, appears to be the key player in iron metabolism. The overexpression of hepcidin is the underlying cause of anemia of inflammation. The identification of compounds inhibiting hepcidin expression could ameliorate anemia associated with inflammation. In the current study, we have demonstrated for the first time that AG490 significantly abolishes hepcidin expression in mice. Our work represents a novel approach to suppress hepcidin expression for treatment of anemia of inflammation and anemias occurring under other conditions.
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Base de dados:
MEDLINE
Assunto principal:
Tirfostinas
/
Peptídeos Catiônicos Antimicrobianos
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Inibidores Enzimáticos
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Ferro
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article