PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats.
J Psychopharmacol
; 26(9): 1265-70, 2012 Sep.
Article
em En
| MEDLINE
| ID: mdl-22182741
ABSTRACT
The α7 nicotinic acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia. Adult female hooded Lister rats received sub-chronic phencyclidine (PCP) (2 mg/kg) or vehicle i.p. twice daily for 7 days, followed by 7 days' washout. PCP-treated rats then received PNU-120596 (10 mg/kg; s.c.) or saline and were tested in the attentional set-shifting task. Sub-chronic PCP produced a significant cognitive deficit in the extra-dimensional shift (EDS) phase of the task (p < 0.001, compared with vehicle). PNU-120596 significantly improved performance of PCP-treated rats in the EDS phase of the attentional set-shifting task (p < 0.001). In conclusion, these data demonstrate that PNU-120596 improves cognitive dysfunction in our animal model of cognitive dysfunction in schizophrenia, most likely via modulation of α7 nACh receptors.
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Base de dados:
MEDLINE
Assunto principal:
Fenciclidina
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Compostos de Fenilureia
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Receptores Nicotínicos
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Transtornos Cognitivos
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Agonistas Nicotínicos
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Fármacos Neuroprotetores
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Síndromes Neurotóxicas
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Isoxazóis
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article