Factors associated with nonadherence to thiopurines in adolescent and adult patients with inflammatory bowel disease.
J Pediatr Gastroenterol Nutr
; 54(5): 685-9, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22197942
ABSTRACT
OBJECTIVES:
We hypothesised that nonadherence to thiopurines is more common in adolescents than in adults with inflammatory bowel disease.METHODS:
We sought factors associated with thiopurine nonadherence defined by thiopurine metabolite levels.RESULTS:
Multivariate logistic regression confirmed that adolescents (odds ratio [OR] 4.6 [95% confidence interval [CI] 1.9-11.5]; P < 0.01) compared with adults, patients with Crohn disease (OR 3.3 [CI 1.1-10.5] P = 0.04) compared with ulcerative colitis, and patients living in more socially deprived areas (OR 1.03 [CI 1.0-1.1] P = 0.02) were more likely to be nonadherent to thiopurines.CONCLUSIONS:
Adolescents are more frequently nonadherent than adults prospective studies are required to determine the reasons for nonadherence in adolescents.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Colite Ulcerativa
/
Doença de Crohn
/
Adesão à Medicação
/
Mercaptopurina
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article