The potential role of glutamate in the current diabetes epidemic.
Acta Diabetol
; 49(3): 167-83, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22218826
ABSTRACT
In the present article, we propose the perspective that abnormal glutamate homeostasis might contribute to diabetes pathogenesis. Previous reports and our recent data indicate that chronically high extracellular glutamate levels exert direct and indirect effects that might participate in the progressive loss of ß-cells occurring in both T1D and T2D. In addition, abnormal glutamate homeostasis may impact all the three accelerators of the "accelerator hypothesis" and could partially explain the rising frequency of T1D and T2D.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácido Glutâmico
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Diabetes Mellitus Tipo 1
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Diabetes Mellitus Tipo 2
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Células Secretoras de Insulina
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article