Novel benzanthrone aminoderivatives for membrane studies.
J Fluoresc
; 22(3): 953-9, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22218973
ABSTRACT
The potential of novel benzanthrone aminoderivatives to trace the changes in physicochemical properties of lipid bilayer has been evaluated. Binding of the dyes to the lipid bilayers composed of zwitterionic phospholipid phosphatidylcholine (PC) and its mixtures with anionic phospholipid cardiolipin (CL) and cholesterol (Chol) was followed by significant quantum yield increase with small blue shift of emission maximum. Analysis of partition coefficients of the dyes under study showed that all aminobenzanthrones possess high lipid-associating ability. The dyes A8 and AM2 proved to be sensitive to the variations in membrane chemical composition responding to the changes in bilayer hydration induced by CL and Chol.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Benzo(a)Antracenos
/
Corantes Fluorescentes
/
Bicamadas Lipídicas
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article