Evidence for epistatic gene interactions between growth factor genes in stroke outcome.
Eur J Neurol
; 19(8): 1151-3, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-22233184
ABSTRACT
BACKGROUND AND PURPOSE:
Growth factors are thought to modulate neurological function in stroke recovery through effects in angiogenesis, neurogenesis, and neuroprotection.METHODS:
We tested the association of variants in the brain-derived neurotrophic factor (BDNF), fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor A (VEGFA) genes, and epistatic interactions between them, with functional outcome in a sample of 546 stroke patients.RESULTS:
While none of the tested genes was independently associated with stroke outcome, two significant gene-gene interaction models were identified. One model combined one BDNF and three FGF2 markers, with a global odds ratio (OR) (95% confidence interval [CI]) of 4.15 [2.86-6.04]. The second model included one FGF2 and two VEGFA markers with a global OR [95% CI] = 2.54 [1.76-3.67].CONCLUSIONS:
The results provide evidence for gene interactions in stroke outcome, highlighting the complexity of the recovery mechanisms after a stroke event.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fator 2 de Crescimento de Fibroblastos
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Fator Neurotrófico Derivado do Encéfalo
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Recuperação de Função Fisiológica
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Acidente Vascular Cerebral
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Fator A de Crescimento do Endotélio Vascular
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Epistasia Genética
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article