Lymphocyte signaling: regulation of FoxO transcription factors by microRNAs.
Ann N Y Acad Sci
; 1247: 46-55, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-22236474
ABSTRACT
The Forkhead box O (FoxO) family of transcription factors is important for the maintenance of immunological homeostasis and tolerance by controlling the development and function of B and T lymphocytes. Because dysregulation in FoxO activity can result in chronic inflammation and autoimmunity, the transcriptional activity of FoxO proteins is tightly controlled and generally dependent on complex posttranslational modifications that lead either to their nuclear entry and subsequent activation or, alternatively, to their nuclear export. The phosphatidylinositol 3-kinase (PI3K)-protein kinase B (PKB/Akt) axis represents the major pathway phosphorylating and thereby inactivating FoxO proteins. However, recent results have revealed an additional posttranscriptional mechanism of FoxO inactivation by microRNAs. The discovery of this molecular pathway may provide a new therapeutic avenue for the modulation of FoxO activity in immune-mediated diseases using either microRNA targeting antagomirs or synthetic microRNA mimics, a topic that is addressed in this review.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos
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Transdução de Sinais
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MicroRNAs
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Fatores de Transcrição Forkhead
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article