Synthesis and antidiabetic activity of 5,7-dihydroxyflavonoids and analogs.
Chem Biodivers
; 9(1): 162-9, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-22253113
ABSTRACT
In a study to evaluate the structural elements essential for the antidiabetic activity of flavonoids, we synthesized two series of flavonoids, 5,7-dihydroxyflavanones and 5,7-dihydroxyflavones. In a screening for potential antidiabetic activity, most of the flavonoids showed a remarkable in vitro activity, and compounds 1f, 2d, and 3c were significantly more effective than the positive control, metformin. The biological activity was mainly affected by structural modification at the ring B moiety of the flavonoid skeleton. The results suggest that 5,7-dihydroxyflavonoids can be considered as promising candidates in the development of new antidiabetic lead compounds.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Flavonoides
/
Flavanonas
/
Hipoglicemiantes
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article