Undiagnosed, untreated acute promyelocytic leukemia presenting as a suspicious sudden death.
J Forensic Sci
; 57(3): 829-31, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22292852
ABSTRACT
Acute promyelocytic leukemia (APL) is a subtype of acute myelogenous leukemia frequently associated with clotting abnormalities and severe hemorrhagic diathesis. The disease is associated with a high incidence of early fatal hemorrhage. We report the sudden death of a 40-year-old male without significant medical history in which foul play had been initially suspected. A thorough postmortem investigation performed on the decedent lead to the diagnosis of APL. Cause of death was a cerebellar hematoma. Underlying APL should be considered in the differential diagnosis when unexplained bleeding is encountered in a decedent. This case emphasizes the value of routinely collecting bone marrow during an autopsy to enable accurate testing and diagnosis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Leucemia Promielocítica Aguda
/
Morte Súbita
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article