Models of cardiovascular disease: measurement of arrhythmogenic/antiarrhythmic activity in the guinea pig.
Curr Protoc Pharmacol
; Chapter 5: Unit 5.1, 2009 Mar.
Article
em En
| MEDLINE
| ID: mdl-22294396
ABSTRACT
The protocols described in this unit are used to assess the effects of new chemical entities on arrhythmias in the guinea pig. In the anesthetized guinea pig, arrhythmias are induced by a slow intravenous infusion of digoxin, which provokes extrasystoles, ventricular tachyarrhythmias, and ultimately cardiac arrest. Imipramine precipitates the occurrence of arrhythmias, whereas propranolol shows protection against them.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Arritmias Cardíacas
/
Protocolos Clínicos
/
Digoxina
/
Modelos Animais de Doenças
/
Antiarrítmicos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article