Cardiac resynchronization therapy in the real world: comparison with the COMPANION study.
J Card Fail
; 18(2): 153-8, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-22300784
ABSTRACT
BACKGROUND:
Several clinical trials have confirmed that cardiac resynchronization therapy (CRT) improves outcomes in well defined patient populations. It is uncertain, however, whether outcomes are similar in real-world clinical settings. This study compared outcomes after CRT with defibrillator (CRT-D) in a large real-world private-practice cardiology setting with those in the COMPANION multicenter trial. METHODS ANDRESULTS:
A total of 429 consecutive patients who received CRT-D for standard indications (group 1) were retrospectively compared with the 595 patients (group 3) in the COMPANION CRT-D cohort regarding survival and survival free of cardiovascular (CV) hospitalization. A subgroup of the group 1 patients who met the COMPANION entrance criteria (group 2) was also compared with the COMPANION cohort (group 3) both with and without propensity-matching statistical analysis. Survival and survival free of CV hospitalization was better in group 1 than in group 3. Survival in group 2 with and without propensity matching was similar to group 3. However, survival free of CV hospitalization was better in the real-world patients (group 2) even after adjustment for differences in baseline characteristics.CONCLUSIONS:
Survival and CV hospitalization outcomes in a real-world clinical setting are as good as, or better than, those demonstrated in the COMPANION research trial.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estimulação Cardíaca Artificial
/
Terapia de Ressincronização Cardíaca
/
Insuficiência Cardíaca
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article