Double transformation of a hematopoietic malignancy and severe associated thrombopathy. Case presentation and review of the literature.
Rom J Intern Med
; 49(2): 137-44, 2011.
Article
em En
| MEDLINE
| ID: mdl-22303605
ABSTRACT
We present the case of a patient with a double transformation during the evolution of chronic hematopoietic malignancy - JAK2 positive chronic myeloproliferative neoplasm; the first transformation had occurred previous to the presentation in our Department, but the second transformation was observed in evolution and it was into a rapidly evolving disease, followed by survival of less than one month. We underline the very poor prognosis -- overall survival of 2.5 years from initial presentation -- a much reduced survival for a chronic myeloproliferative neoplasm, probably due also to multiple associated pathology. Also, the other interesting element of the case is related to the dysfunctional platelets -- hemorrhagic complication at increased platelet count, respectively thrombosis at platelet count under 20000/mmc.
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Base de dados:
MEDLINE
Assunto principal:
Policitemia Vera
/
Leucemia Mieloide Aguda
/
Transformação Celular Neoplásica
/
Mielofibrose Primária
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article