Pannexin 1 forms an anion-selective channel.
Pflugers Arch
; 463(4): 585-92, 2012 Apr.
Article
em En
| MEDLINE
| ID: mdl-22311122
ABSTRACT
Pannexin 1 (Panx1) is expressed in various mammalian tissues including the brain and immune cells. Here, we present evidence that Panx1 when expressed in mammalian cells, forms anion-selective channels, with a rank order of permeabilities NO (3) (-)> I(-) > Br (-)> Cl (-) > F (-)>> aspartate (-)≈ glutamate (-)≈ gluconate(-). Single-channel Panx1-mediated currents have a unitary conductance around 68 pS. Our results show that Panx1 assembles into a membrane anion channel with a relatively low single-channel conductance.
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Base de dados:
MEDLINE
Assunto principal:
Permeabilidade da Membrana Celular
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Conexinas
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Canais de Ânion Dependentes de Voltagem
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Ânions
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Proteínas do Tecido Nervoso
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article