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Increased levels of CD4 T-cell activation in individuals with CXCR4 using viruses in primary HIV-1 infection.
AIDS ; 26(7): 887-90, 2012 Apr 24.
Article em En | MEDLINE | ID: mdl-22313951
CXCR4-tropic (X4) HIV-1 variants are associated with faster disease progression compared with CCR5-tropic variants; however, the mechanism for this is unclear. We measured T-cell activation in 120 individuals with primary HIV-1 infection. X4-utilizing variants, determined genotypically, were present in 8.3% of the participants and were associated with higher levels of CD4 T-cell activation, even after adjusting for other prognostic factors. Increased CD4 T-cell activation may influence the more rapid immunological decline associated with X4 virus.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Linfócitos T CD4-Positivos / Infecções por HIV / HIV-1 / Receptores CXCR4 Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Linfócitos T CD4-Positivos / Infecções por HIV / HIV-1 / Receptores CXCR4 Idioma: En Ano de publicação: 2012 Tipo de documento: Article