Planned neck dissection before combined chemoradiation in organ preservation protocol for N2-N3 of supraglottic or hypopharyngeal carcinoma.
ORL J Otorhinolaryngol Relat Spec
; 74(2): 64-9, 2012.
Article
em En
| MEDLINE
| ID: mdl-22327028
ABSTRACT
OBJECTIVE:
To investigate the clinical therapeutic outcomes and neck node control of a pretreatment neck dissection in the chemoradiation protocol of organ preservation for N2-N3 of supraglottic and hypopharyngeal carcinoma.METHODS:
Forty-six patients (group A) with untreated N2 or N3 squamous cell carcinoma of the supraglottis or hypopharynx underwent pretreatment neck dissection in a chemoradiation protocol, while 39 patients (group B) did not undergo pretreatment neck dissection in a chemoradiation protocol. Salvage surgeries were used for local or cervical node residual tumor or recurrence after chemoradiotherapy.RESULTS:
In group A, the mean time between neck dissection and chemoradiation was 21 days (range 15-29). Only 3 patients (6.5%) experienced wound complications. A 'boost' of radiation of 12 Gy was delivered after 33 neck dissections (64.8%) in patients with extracapsular spread. The Kaplan-Meier 5-year overall survival rate was 42.5%. The 5-year overall survival rate and disease-specific survival rate in group A was 42.5 and 46.4%. The rate of neck node control in group A was better than that in group B (86.3 vs. 65.9%, p = 0.02).CONCLUSIONS:
Pretreatment neck dissection in a chemoradiation protocol for supraglottic or hypopharyngeal carcinoma showed low complication rates, no delay for radiation, optimal radiation doses, and a high nodal disease control.
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Base de dados:
MEDLINE
Assunto principal:
Esvaziamento Cervical
/
Carcinoma de Células Escamosas
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Neoplasias Hipofaríngeas
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Quimiorradioterapia
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Neoplasias de Cabeça e Pescoço
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article