Osteoclast stimulatory transmembrane protein and dendritic cellspecific transmembrane protein cooperatively modulate cellcell fusion to form osteoclasts and foreign body giant cells.
J Bone Miner Res
; 27(6): 1289-97, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22337159
ABSTRACT
Cellcell fusion is a dynamic phenomenon promoting cytoskeletal reorganization and phenotypic changes. To characterize factors essential for fusion of macrophage lineage cells, we identified the multitransmembrane protein, osteoclast stimulatory transmembrane protein (OC-STAMP), and analyzed its function. OC-STAMPdeficient mice exhibited a complete lack of cellcell fusion of osteoclasts and foreign body giant cells (FBGCs), both of which are macrophage-lineage multinuclear cells, although expression of dendritic cell specific transmembrane protein (DC-STAMP), which is also essential for osteoclast/FBGC fusion, was normal. Crossing OC-STAMPoverexpressing transgenic mice with OC-STAMPdeficient mice restored inhibited osteoclast and FBGC cellcell fusion seen in OC-STAMPdeficient mice. Thus, fusogenic mechanisms in macrophage-lineage cells are regulated via OC-STAMP and DC-STAMP.
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Base de dados:
MEDLINE
Assunto principal:
Osteoclastos
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Células Gigantes de Corpo Estranho
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Proteínas de Membrana
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Proteínas do Tecido Nervoso
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article