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IQGAP1: a regulator of intracellular spacetime relativity.
Malarkannan, Subramaniam; Awasthi, Aradhana; Rajasekaran, Kamalakannan; Kumar, Pawan; Schuldt, Kristina M; Bartoszek, Allison; Manoharan, Niranjan; Goldner, Nicholas K; Umhoefer, Colleen M; Thakar, Monica S.
Afiliação
  • Malarkannan S; Laboratory of Molecular Immunology and Immunotherapy, Blood Research Institute, Milwaukee, WI 53226, USA. subra.malar@bcw.edu
J Immunol ; 188(5): 2057-63, 2012 Mar 01.
Article em En | MEDLINE | ID: mdl-22345702
ABSTRACT
Activating and inhibiting receptors of lymphocytes collect valuable information about their mikròs kósmos. This information is essential to initiate or to turn off complex signaling pathways. Irrespective of these advances, our knowledge on how these intracellular activation cascades are coordinated in a spatiotemporal manner is far from complete. Among multiple explanations, the scaffolding proteins have emerged as a critical piece of this evolutionary tangram. Among many, IQGAP1 is one of the essential scaffolding proteins that coordinate multiple signaling pathways. IQGAP1 possesses multiple protein interaction motifs to achieve its scaffolding functions. Using these domains, IQGAP1 has been shown to regulate a number of essential cellular events. This includes actin polymerization, tubulin multimerization, microtubule organizing center formation, calcium/calmodulin signaling, Pak/Raf/Mek1/2-mediated Erk1/2 activation, formation of maestrosome, E-cadherin, and CD44-mediated signaling and glycogen synthase kinase-3/adenomatous polyposis coli-mediated ß-catenin activation. In this review, we summarize the recent developments and exciting new findings of cellular functions of IQGAP1.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Comunicação Celular / Subpopulações de Linfócitos / Proteínas Ativadoras de ras GTPase / Espaço Intracelular / Multimerização Proteica Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Comunicação Celular / Subpopulações de Linfócitos / Proteínas Ativadoras de ras GTPase / Espaço Intracelular / Multimerização Proteica Idioma: En Ano de publicação: 2012 Tipo de documento: Article