A short-term toxicity study of Aspergillus carbonarius carotenoid.
Int J Toxicol
; 31(2): 158-65, 2012 Mar.
Article
em En
| MEDLINE
| ID: mdl-22366116
ABSTRACT
In a pharmacokinetic study, high-performance liquid chromatography analysis of blood samples of Wistar female rats fed with partially saturated canthaxanthin (PSC) of Aspergillus carbonarius showed the presence of the carotenoid in the plasma within 6 hours of feeding. In another study for safety assessment of PSC fed to rats over a period of 28 days at 0.05%, 0.10%, and 0.25%, the rats showed no changes in food intake. There were no significant differences observed in body weight, hematological parameters, or serum clinical enzymes compared to the control group not fed with PSC. Deposition of PSC in the eyes of the rats was also not observed. The results showed that PSC-fed rats were not adversely affected as far as toxicological studies were concerned.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aspergillus
/
Cantaxantina
/
Corantes
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Aditivos Alimentares
/
Antioxidantes
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article