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Dimethyl acetals, an indirect marker of the endogenous antioxidant plasmalogen level, are reduced in blood lipids of Sudanese pre-eclamptic subjects whose background diet is high in carbohydrate.
Bueno, A A; Ghebremeskel, K; Bakheit, K H; Elbashir, M I; Adam, I.
Afiliação
  • Bueno AA; Institute of Brain Chemistry and Human Nutrition, London Metropolitan University, UK. a.amadorbueno@londonmet.ac.uk
J Obstet Gynaecol ; 32(3): 241-6, 2012 Apr.
Article em En | MEDLINE | ID: mdl-22369396
In Sudanese women with (n = 60) and without (n = 65) pre-eclampsia, circulating lipids, plasma and red cell saturated and monounsaturated fatty (MUFA) acids and dimethyl acetals (DMAs) were investigated. DMAs are an indirect marker of levels of plasmalogens, endogenous antioxidants, which play a critical role in oxidative protection, and cholesterol homeostasis. The pre-eclamptics had higher C18:1n-9 (p < 0.001) and ΣMUFA (p < 0.01) in plasma free fatty acids, C16:1n-7, C18:1n-9, ΣMUFA; 16:0/16:1n-7 (p < 0.01) in erythrocyte choline phosphoglycerides (ePC) and 16:1n-7, 18:1n-7 and 16:0/16:1n-7 (p < 0.01) in erythrocyte ethanolamine phosphoglycerides (ePE). In contrast, the DMAs 18:0, 18:1 and ΣDMAs in ePE, and 16:0, 18:0 and ΣDMAs in ePC were reduced (p < 0.001) in the pre-eclamptic women. This study of pregnant women with high carbohydrate and low fat background diet suggests pre-eclampsia is associated with oxidative stress and enhanced activity of the microsomal enzyme stearyl-CoA desaturase (delta 9 desaturase), as assessed by palmitic/palmitoleic (C16:0/C16:n-1) and stearic/oleic (C18/C18:1n-9) ratios.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pré-Eclâmpsia / Carboidratos da Dieta / Dieta / Eritrócitos / Ácidos Graxos / Acetais Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pré-Eclâmpsia / Carboidratos da Dieta / Dieta / Eritrócitos / Ácidos Graxos / Acetais Idioma: En Ano de publicação: 2012 Tipo de documento: Article