Effects of valsartan versus olmesartan addition to amlodipine/hydrochlorothiazide combination in treating stage 2 hypertensive patients.
Expert Opin Pharmacother
; 13(5): 629-36, 2012 04.
Article
em En
| MEDLINE
| ID: mdl-22372508
ABSTRACT
OBJECTIVE:
The objective of this study was to assess the effects of valsartan or olmesartan addition to dual therapy with amlodipine + hydrochlorothiazide (HCTZ) in the treatment of stage 2 hypertension. RESEARCH DESIGN ANDMETHODS:
180 patients with diastolic blood pressure (DBP) ≥ 99 and < 110 mm Hg were treated with amlodipine 5 mg + HCTZ 12.5 mg combination. After 4 weeks, 149 patients whose blood pressure (BP) was not controlled, were randomized to the combination of valsartan 160 mg + amlodipine 5 mg + HCTZ 12.5 mg or olmesartan 20 mg + amlodipine 5 mg + HCTZ 12.5 mg for 4 weeks. MAIN OUTCOMEMEASURES:
At the end of each period, clinical and ambulatory BP measurements were recorded.RESULTS:
Both triple combinations produced greater ambulatory and clinical SBP/DBP reduction than dual therapy. However, mean reduction from baseline in the valsartan + amlodipine + HCTZ-treated patients was significantly greater than in the olmesartan + amlodipine + HCTZ-treated patients. Compared with dual therapy, the add-on effect of valsartan was significantly greater than that of olmesartan, the difference being more evident for nighttime SBP/DBP values (-3.3 (95% CI 0.44 - 3.51)/3.0 (95% CI 0.59 - 3.34) mm Hg, p < 0.01).CONCLUSIONS:
The addition of valsartan to amlodipine + HCTZ produced greater BP reduction than the addition of olmesartan.
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Base de dados:
MEDLINE
Assunto principal:
Bloqueadores do Receptor Tipo 1 de Angiotensina II
/
Hipertensão
/
Anti-Hipertensivos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article