Clinical indicators for pulmonary arterial hypertension in thalassemia.
J Med Assoc Thai
; 95(1): 16-21, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-22379736
ABSTRACT
OBJECTIVE:
To explore clinical indicators for pulmonary arterial hypertension (PAH) in thalassemia (Thal). MATERIAL ANDMETHOD:
A study was conducted in thalassemia patients at Chiang Rai Hospital, Chiang Rai, Thailand. Pulmonary artery systolic pressure (PASP) was determined by doppler echocardiography and PAH was defined as PASP > 35 mmHg. Patient characteristics were extracted from medical records. Characteristics of patients with and without PAH were compared. Risk indicators were explored with logistic regression analysis.RESULTS:
Two hundred twenty four patients were included, 144 E/beta-Thal, 37 homozygous beta-Thal and 43 Hb H disease. There were 65 patients (29.0%) with PAH, 53 (81.5%) with E/beta-Thal, 8 (12.3%) with homozygous beta-Thal and 4 (6.2%) with Hb H disease. In a multivariable analysis, features significantly associated with PAH were E/beta-Thal (OR = 1.98, 95% CI; 1.29-3.01) and post splenectomy status (OR = 2.36, 95% CI; 1.17-4.73).CONCLUSION:
Significant indicators for PAH in thalassemia were E/beta-Thal and post splenectomy status.
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Base de dados:
MEDLINE
Assunto principal:
Artéria Pulmonar
/
Talassemia
/
Hipertensão Pulmonar
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article