Acquisition and generalization of fear conditioning are not modulated by the BDNF-val66met polymorphism in humans.
Psychophysiology
; 49(5): 713-9, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22404164
ABSTRACT
Few studies have investigated the role of the BDNF-val66met polymorphism in fear conditioning in humans, and previous results have been inconsistent. In the present study, we examined whether the BDNF-val66met was associated with differences in the acquisition and generalization of fear during a differential conditioning paradigm in a large sample of participants (N = 141). Using three different indexes of fear learning (fear-potentiated startle, skin conductance response, and online risk ratings) no effects of the BDNF-val66met were found either on the acquisition or the generalization of conditioned fear. Taken together with previous data, our study suggests that the BDNF-val66met polymorphism has no effect on the acquisition or generalization of fear.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Condicionamento Psicológico
/
Fator Neurotrófico Derivado do Encéfalo
/
Medo
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article