Antilipidemic agents, III: Synthesis of some heterocyclic derivatives of beta-sitosterol.
Arch Pharm (Weinheim)
; 323(7): 401-4, 1990 Jul.
Article
em En
| MEDLINE
| ID: mdl-2241533
ABSTRACT
Four novel series of heterocyclic derivatives of beta-sitosterol were prepared by the reaction of 3-beta-sitosterol hemisuccinate with SOCl2 then with thiols, amines or phenols. These series are 3 beta-[(3-substituted-4(3H)-quinazolinon-2- yl)thiocarbonylproprionyloxy]stigmast-5-ene; 3 beta- ([4-substituted-5-(4-pyridyl)-4H-1,2,4-triazol-3-yl] thiocarbonylpropionyloxy)stigmast-5-ene; 3 beta- [(5-substituted-1,3,4-thiadiazol-2-yl)carbamoylpropionyloxy] stigmast-5-ene and 3 beta-(substituted carbamoyl or oxycarbonylpropionyloxy)stigmast-5-ene. The antilipidemic activity of representative compounds was studied.
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Base de dados:
MEDLINE
Assunto principal:
Sitosteroides
/
Hipolipemiantes
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article