Accumulation and depletion kinetics of erythromycin in rainbow trout (Oncorhynchus mykiss).
Prev Vet Med
; 105(1-2): 160-3, 2012 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-22436556
ABSTRACT
Erythromycin is an antimicrobial agent recommended for the control and treatment of diseases caused by gram-positive bacteria. Few studies, however, have determined the metabolic and pharmacokinetic aspects of this antimicrobial agent in fish. The aim of the present study, therefore, was to determine the accumulation and depletion time of erythromycin after administration of medicated feed containing 52 mg kg(-1) body weight day(-1) for 8 days in rainbow trout (Oncorhynchus mykiss). Results were analyzed following the European Agency for Evaluation of Medicinal Products guidelines. We measured a withdrawal time of 187°C-day (°C-day=water temperature×days), lower than the value (500°C-day) recommended by Council Directive 2004/28/EC for veterinary medicinal products. Our results provide data to establish therapeutic regimens for the use of erythromycin in aquaculture.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Resíduos de Drogas
/
Eritromicina
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Oncorhynchus mykiss
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Antibacterianos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article