An analysis of a second-line S-1 monotherapy for gemcitabine-refractory biliary tract cancer.
Hepatogastroenterology
; 59(115): 691-5, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22469710
ABSTRACT
BACKGROUND/AIMS:
Gemcitabine is widely used as a first-line therapy for biliary tract cancer (BTC). However, few studies have been conducted to analyze second- line therapies.METHODOLOGY:
From 33 patients who had been administered gemcitabine following resection between May 2005 and August 2007, we retrospectively analyzed the safety and efficacy of S-1 in 11 cases who received S-1 as second-line therapy due to recurrence or relapse of the primary disease.RESULTS:
Among the adverse events (AEs) observed during S-1 administration, the most common was a decrease in the concentration of hemoglobin, followed by thrombocytopenia. No Grade 4 AEs or worse were detected. In addition, the AEs and their respective severity strongly resembled those of gemcitabine used as a first-line therapy. There were 7 cases that could be evaluated according to RECIST criteria, of which 1 was considered in the partial response and 3 as stable disease. The medians of time to progression after S-1 administration and survival after S-1 administration were 5.6 months and 31 months, respectively.CONCLUSIONS:
S-1 could be taken safely as a second-line therapy without provoking severe AEs. By preventing the cessation of S-1 administration due to its AEs, more continued S-1 administration could lead to a better prognosis for BTC.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Ácido Oxônico
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Neoplasias do Sistema Biliar
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Tegafur
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Resistencia a Medicamentos Antineoplásicos
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Desoxicitidina
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Recidiva Local de Neoplasia
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Antimetabólitos Antineoplásicos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article