Your browser doesn't support javascript.
loading
Safety and efficacy of a quinolone-based regimen for treatment of tuberculosis in renal transplant recipients.
Yoon, H E; Jeon, Y J; Chung, H W; Shin, S J; Hwang, H S; Lee, S J; Chang, Y K; Choi, B S; Park, C W; Kim, Y S; Kim, S Y; Yang, C W.
Afiliação
  • Yoon HE; Division of Nephrology, Department of Internal Medicine, Incheon St Mary's Hospital, Catholic University of Korea, Incheon, Korea.
Transplant Proc ; 44(3): 730-3, 2012 Apr.
Article em En | MEDLINE | ID: mdl-22483479
ABSTRACT

BACKGROUND:

Rifampin (RFP) is a first-line antituberculosis drug, but it increases the risk of acute rejection (AR) in transplant recipients. This study evaluated whether quinolone (QNL) can replace RFP in renal transplant recipients with tuberculosis.

METHODS:

One hundred nine patients with active tuberculosis were included. Patients consisted of RFP (n = 91) and QNL (n = 18) groups based on the initial treatment regimen. Patients with RFP-associated adverse effects were subdivided into RFP-maintenance (RFP-M; n = 18) and QNL-conversion (QNL-C; n = 8) groups. Clinical outcomes were compared between groups.

RESULTS:

The incidence of AR was higher in the RFP group than in the QNL group (24.2% vs 5.6%). The QNL group showed significantly higher 10-year graft survival rates than the RFP group (88.1% vs 66.5%; P = .022). The QNL-C group showed significantly higher 10-year graft survival rates than the RFP-M group (87.5% vs 27.8%; P = .011). The rate of complete functional recovery after AR was higher in the QNL-C group than in the RFP-M group (50% vs 22.2%).

CONCLUSIONS:

A QNL-based regimen may be safe and effective for treatment of tuberculosis and may lower the risk of graft failure in renal transplant recipients.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose / Transplante de Rim / Quinolonas / Antituberculosos Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose / Transplante de Rim / Quinolonas / Antituberculosos Idioma: En Ano de publicação: 2012 Tipo de documento: Article