[Lipid, lipoproteins and atherogenesis profiles in sickle cell disease among Central African patients]. / Évaluation du profil lipoprotéique et du risque athérogène chez les drépanocytaires homozygotes et hétérozygotes de Brazzaville.
Ann Biol Clin (Paris)
; 70(2): 183-8, 2012.
Article
em Fr
| MEDLINE
| ID: mdl-22484529
ABSTRACT
Lipid and lipopproteins disorders are well established in sera from sickle cell disease (SCD) patients out of Central Africa. The present case-control study was conducted to compare serum levels of total cholesterol (TC), HDL-C, triglycerides (TG), LDL-C and TC/HDL-C ratio (atherogenic index) from SCD homozygotes (SS) in steady state, SCD heterozygotes (AS) and controls (AA) in Brazzaville, Congo. Significant reductions of TC and LDL-C vs. increase in TG were reported in SS. However, significant decrease in HDL-C and increase in atherogenic index were observed in AS. We recommend prevention of oxidative stress, dyslipidemia and atherosclerosis in SCD using hygiene-diet measures. Only longitudinal studies in large populations will provide pathophysiological basis of lipid and lipoproteins disorders in SCD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aterosclerose
/
Anemia Falciforme
/
Lipídeos
/
Lipoproteínas
Idioma:
Fr
Ano de publicação:
2012
Tipo de documento:
Article