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Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies.
Bresnick, Emery H; Katsumura, Koichi R; Lee, Hsiang-Ying; Johnson, Kirby D; Perkins, Archibald S.
Afiliação
  • Bresnick EH; Wisconsin Institutes for Medical Research, Paul Carbone Cancer Center, Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA. ehbresni@wisc.edu
Nucleic Acids Res ; 40(13): 5819-31, 2012 Jul.
Article em En | MEDLINE | ID: mdl-22492510
Numerous examples exist of how disrupting the actions of physiological regulators of blood cell development yields hematologic malignancies. The master regulator of hematopoietic stem/progenitor cells GATA-2 was cloned almost 20 years ago, and elegant genetic analyses demonstrated its essential function to promote hematopoiesis. While certain GATA-2 target genes are implicated in leukemogenesis, only recently have definitive insights emerged linking GATA-2 to human hematologic pathophysiologies. These pathophysiologies include myelodysplastic syndrome, acute myeloid leukemia and an immunodeficiency syndrome with complex phenotypes including leukemia. As GATA-2 has a pivotal role in the etiology of human cancer, it is instructive to consider mechanisms underlying normal GATA factor function/regulation and how dissecting such mechanisms may reveal unique opportunities for thwarting GATA-2-dependent processes in a therapeutic context. This article highlights GATA factor mechanistic principles, with a heavy emphasis on GATA-1 and GATA-2 functions in the hematopoietic system, and new links between GATA-2 dysregulation and human pathophysiologies.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Hematológicas / Fatores de Transcrição GATA Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Hematológicas / Fatores de Transcrição GATA Idioma: En Ano de publicação: 2012 Tipo de documento: Article