Adhesion molecule CADM1 contributes to gap junctional communication among pancreatic islet &#945;-cells and prevents their excessive secretion of glucagon.

Ito, Akihiko; Ichiyanagi, Naoki; Ikeda, Yuki; Hagiyama, Man; Inoue, Takao; Kimura, Keiko B; Sakurai, Minami A; Hamaguchi, Kazuyuki; Murakami, Yoshinori

Adhesion molecule CADM1 contributes to gap junctional communication among pancreatic islet α-cells and prevents their excessive secretion of glucagon.

Ito, Akihiko; Ichiyanagi, Naoki; Ikeda, Yuki; Hagiyama, Man; Inoue, Takao; Kimura, Keiko B; Sakurai, Minami A; Hamaguchi, Kazuyuki; Murakami, Yoshinori.

Afiliação

Ito A; Division of Molecular Pathology; Institute of Medical Science; University of Tokyo; Tokyo, Japan; Department of Pathology; Faculty of Medicine; Kinki University; Osaka, Japan.
Ichiyanagi N; Division of Molecular Pathology; Institute of Medical Science; University of Tokyo; Tokyo, Japan.
Ikeda Y; Division of Molecular Pathology; Institute of Medical Science; University of Tokyo; Tokyo, Japan.
Hagiyama M; Division of Molecular Pathology; Institute of Medical Science; University of Tokyo; Tokyo, Japan; Department of Pathology; Faculty of Medicine; Kinki University; Osaka, Japan.
Inoue T; Department of Pathology; Faculty of Medicine; Kinki University; Osaka, Japan.
Kimura KB; Division of Molecular Pathology; Institute of Medical Science; University of Tokyo; Tokyo, Japan.
Sakurai MA; Department of Pathology; Faculty of Medicine; Kinki University; Osaka, Japan; Department of Molecular Genetics; Research Institute for Microbial Diseases; Osaka University; Osaka, Japan.
Hamaguchi K; Department of Community Health and Gerontological Nursing; Faculty of Medicine; Oita University; Oita, Japan.
Murakami Y; Division of Molecular Pathology; Institute of Medical Science; University of Tokyo; Tokyo, Japan.

Islets ; 4(1): 49-55, 2012.

Article em En | MEDLINE | ID: mdl-22513384

Assuntos

Moléculas de Adesão Celular/metabolismo; Comunicação Celular; Junções Comunicantes/metabolismo; Células Secretoras de Glucagon/metabolismo; Glucagon/metabolismo; Imunoglobulinas/metabolismo; Peptídeos e Proteínas de Sinalização Intercelular/metabolismo; Ilhotas Pancreáticas/metabolismo; Animais; Adesão Celular; Molécula 1 de Adesão Celular; Moléculas de Adesão Celular/genética; Membrana Celular/química; Células Cultivadas; Conexinas/análise; Citoplasma/química; Células Secretoras de Glucagon/química; Imunoglobulinas/genética; Camundongos; Camundongos Knockout; RNA Interferente Pequeno; Proteína delta-2 de Junções Comunicantes

Palavras-chave

Necl-2; SynCAM; cell-cell interaction; connexin; diabetes mellitus; hyperglucagonemia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoglobulinas / Glucagon / Moléculas de Adesão Celular / Comunicação Celular / Ilhotas Pancreáticas / Junções Comunicantes / Peptídeos e Proteínas de Sinalização Intercelular / Células Secretoras de Glucagon Idioma: En Ano de publicação: 2012 Tipo de documento: Article

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