Prospects for gene transfer for clinical heart failure.
Gene Ther
; 19(6): 606-12, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22534469
ABSTRACT
Congestive heart failure is an inexorable disease associated with unacceptably high morbidity and mortality. Preclinical results indicate that gene transfer using various proteins is a safe and effective approach for increasing function of the failing heart. In the current review, we provide a summary of cardiac gene transfer in general and summarize findings using adenylyl cyclase 6 as therapeutic gene in the failing heart. We also discuss the potential usefulness of a new treatment for congestive heart failure, paracrine-based gene transfer.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terapia Genética
/
Adenilil Ciclases
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Comunicação Parácrina
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Insuficiência Cardíaca
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article