Prevention of early-onset pneumonia in surgical patients by chemoprophylaxis.
Am J Surg
; 204(4): 441-6, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-22537471
ABSTRACT
BACKGROUND:
The purpose of this study was to explore the impact of surgical antimicrobial chemoprophylaxis on the prevention of early-onset postsurgical pneumonia (EOPP) using a logistic regression model that included the principal risk or confusion factors associated with incidence of early-onset postsurgical pneumonia. MATERIALS ANDMETHODS:
The sample chosen corresponded to 13 years during which the epidemiological surveillance system was in place in the general and digestive surgery department (N = 13,024 patients) and was designed as a prospective cohort study. Risk factors associated with EOPP development were analyzed using a cohort-nested case-control study.RESULTS:
Cumulative incidence of EOPP in this series of patients was .6%, accounting for 24.7% of total nosocomial pneumonias. The multivariate model showed the following risks or confusion factors for EOPP age, emergency admission, type of surgery, duration of surgical intervention, infection on admission, and antimicrobial chemoprophylaxis (administered, odds ratio = .18; 95% confidence interval, .09-.33).CONCLUSIONS:
Surgical antimicrobial chemoprophylaxis was associated as an independent factor with incidence reduction of early-onset postsurgical pneumonia, and, aside from its known effect on surgical site infection, its administration, where indicated, is useful for the prevention of early-onset postsurgical pneumonia.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pneumonia
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Complicações Pós-Operatórias
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Procedimentos Cirúrgicos Operatórios
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Infecção Hospitalar
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Antibioticoprofilaxia
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article