Adrenodoxin--a versatile ferredoxin.
IUBMB Life
; 64(6): 506-12, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22556163
ABSTRACT
Mammalian adrenodoxin (Adx) has been known for many years as an essential electron mediator in mitochondrial cytochrome P450 systems. Because of its ability to support several cytochrome P450 enzymes, it is involved not only in adrenal steroid hormone biosynthesis but also in vitamin D and bile acid metabolism. Recently, Adx is increasingly gaining attention because of its potential for pharmaceutical industry and biotechnology. With human cytochromes P450 becoming important drug targets, suitable Adx-based screening systems have to be developed to test putative new drugs. Moreover, in artificial systems, Adx has been shown to functionally interact with diverse bacterial cytochromes P450 catalyzing a variety of chemically interesting reactions. Putative biotechnological applications of such Adx-containing reconstituted systems are discussed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Adrenodoxina
/
Ferredoxinas
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article