Novel benzimidazole analogs as inhibitors of EGFR tyrosine kinase.
Chem Biol Drug Des
; 80(4): 625-30, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-22564276
ABSTRACT
A series of new benzimidazole congeners were synthesized, and their structures were elucidated on the basis of elemental analyses and spectral studies (¹H NMR, FT-IR and EI-MS). Preliminary pharmacokinetic studies showed a promising outlook for further in vivo evaluation. The newly synthesized compounds were tested in vitro on human breast carcinoma cell line (MCF-7) in which EGFR is highly expressed. Most of the tested compounds exhibited antitumor activity with IC50 values in the micro to nano molar range.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Benzimidazóis
/
Neoplasias da Mama
/
Receptores ErbB
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Antineoplásicos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article