Evaluation of mass-forming intrahepatic cholangiocarcinoma with viral hepatitis.
Hepatogastroenterology
; 59(116): 1217-9, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22580675
ABSTRACT
BACKGROUND/AIMS:
The correlation between the mass-forming type of intrahepatic cholangiocarcinoma (ICC) and the infection of the hepatitis B virus and hepatitis C virus are poorly understood. In this study, the clinical features of 34 patients with the mass-forming type ICC were reviewed to evaluate prognostic determinants.METHODOLOGY:
Between January 1997 and December 2007, 34 patients underwent surgical resection for the mass-forming type of ICC in Kumamoto University Hospital. The significance of 14 clinicopathological factors consisting of age, gender, CA19-9 levels, CEA levels, size, intrahepatic metastases, portal vein invasion, bile duct invasion, histological differentiation, lymph node involvement, type B or C hepatitis, lymph node dissection, Sirius Red score of the tumor and platelet count in peripheral blood were analyzed, with regard to prognostic aspect.RESULTS:
Univariate analysis showed that significant risk factors for poor survival included age =65 years, CEA levels =1.6ng/mL and pathological lymph node involvement. Multivariate analysis revealed that age, CEA levels and lymph node involvement were independent and significant poor prognostic factors.CONCLUSIONS:
It was concluded that age, CEA levels and lymph node involvement were significantly poor prognostic factors. However, the infection with type B or C hepatitis was not a prognostic factor of the mass forming type ICC.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Colangiocarcinoma
/
Neoplasias Hepáticas
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article