PTK7 as a novel marker for favorable gastric cancer patient survival.
J Surg Oncol
; 106(7): 880-6, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-22585737
ABSTRACT
BACKGROUND AND OBJECTIVES:
Protein tyrosine kinase 7 (PTK7) plays important functions in several cancer types but its expression in gastric cancer remains unknown. This study was designed to investigate PTK7 expression in gastric cancer.METHODS:
PTK7 expression was assessed by immunohistochemistry in 201 gastric cancer patients. The relationship between PTK7 expression and clinicopathological features and patients prognosis were statistically analyzed.RESULTS:
PTK7 expression was detected in 56.72% (114 of 201) of gastric cancer patients. The immunostaining was predominantly localized in the cytoplasm. The statistical analyses showed that PTK7 expression was more frequently detected in patients with well-differentiated tumors (P = 0.001). Furthermore, PTK7 expression was significantly related to the favorable overall survival (OS; P = 0.012) and disease-free survival (DFS; P = 0.009). Multivariate Cox regression analyses revealed that PTK7 expression was an independent prognostic factor for both favorable OS (P = 0.028) and DFS (P = 0.012).CONCLUSION:
Our findings demonstrate that PTK7 can serve as a novel prognostic biomarker for gastric cancer patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Biomarcadores Tumorais
/
Moléculas de Adesão Celular
/
Receptores Proteína Tirosina Quinases
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article