Doubly biomimetic catecholic phosphorylcholine copolymer: a platform strategy for fabricating antifouling surfaces.
Macromol Biosci
; 12(7): 979-85, 2012 Jul.
Article
em En
| MEDLINE
| ID: mdl-22610777
ABSTRACT
A doubly biomimetic PMNC polymer bearing cell antifouling phosphorylcholine and mussel adhesive protein catechol groups is synthesized. The polymer can be deposited onto a variety of substrates by dip-coating in an aqueous solution, adhering to surfaces via the catechol functional group while at the same time forming a cell outer membrane mimetic antifouling surface. Contact angle, ATR-FTIR and XPS measurements confirm polymer coating formation on a variety of inorganic and organic substrates. BSA and bovine plasma fibrinogen protein adsorption on PMNC coated surfaces are reduced significantly compared to unmodified substrates, and platelet adhesion from human serum onto the PMNC coated substrate surfaces is highly suppressed in this study.
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Base de dados:
MEDLINE
Assunto principal:
Fosforilcolina
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Proteínas
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Catecóis
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Materiais Revestidos Biocompatíveis
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Materiais Biomiméticos
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Desinfetantes
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article