Synthesis of Leubethanol derivatives and evaluation against Mycobacterium tuberculosis.
Bioorg Med Chem
; 20(13): 4155-63, 2012 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-22626551
ABSTRACT
Twenty-five derivatives of the natural diterpene leubethanol, including several potential pro-drugs, with changes in the functionality of the aliphatic chain or modifications of the phenolic group, were synthesized and tested in vitro by the MABA technique for their activity against the H37Rv strain of Mycobacterium tuberculosis. Several compounds showed antimycobacterial potencies similar to that of the lead compound and two of them displayed higher selectivity indexes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diterpenos
/
Mycobacterium tuberculosis
/
Antituberculosos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article