Retinoblastoma: value of dynamic contrast-enhanced MR imaging and correlation with tumor angiogenesis.
AJNR Am J Neuroradiol
; 33(11): 2129-35, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-22627800
ABSTRACT
BACKGROUND AND PURPOSE:
Noninvasive evaluation of retinoblastoma treatment response has become more important due to increased use of eye-sparing treatments. We evaluated the relation between DCE-MR imaging and histopathologic parameters to determine the value of DCE-MR imaging in assessing tumor angiogenesis and prognostic features. MATERIALS ANDMETHODS:
Fifteen consecutive patients with retinoblastoma (mean age, 24 months; range, 2-70 months) undergoing enucleation as the primary treatment (15 eyes) were scanned at 1.5T by using dedicated surface coils. Pretreatment DCE-MR imaging of the most affected eye was evaluated by 2 observers by using curve-pattern analysis, with the first 5 minutes of each curve and the full time-series described as κ(5min) and κ(17min), respectively. Assessed histopathologic and immunologic parameters included optic nerve invasion, choroid invasion, MVD, tumor necrosis, and expression of VEGF and Flt-1.RESULTS:
The median value of κ(5min) was 1.28 (range, 0.87-2.07) and correlated positively with MVD (P = .008). The median value of κ(17min) was 1.33 (range, 0.35-3.08) and correlated negatively with tumor necrosis (P = .002). Other histopathologic and immunohistopathologic parameters did not correlate with DCE-MR imaging parameters. Interobserver agreement was 0.53 for κ(5min) and 0.91 for κ(17min).CONCLUSIONS:
In retinoblastoma, the early phase of the DCE time curve positively correlates with MVD, while the presence of late enhancement is correlated with necrosis. Thus, the potential for DCE-MR imaging to noninvasively assess tumor angiogenesis and necrosis in retinoblastoma is promising and warrants further investigation.
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Base de dados:
MEDLINE
Assunto principal:
Retinoblastoma
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Imageamento por Ressonância Magnética
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Neoplasias da Retina
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Neovascularização Patológica
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article