JAK2 and genomic instability in the myeloproliferative neoplasms: a case of the chicken or the egg?
Am J Hematol
; 87(11): 1028-36, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-22641564
ABSTRACT
The myeloproliferative neoplasms (MPNs) are a particularly useful model for studying mutation accumulation in neoplastic cells, and the mechanisms underlying their acquisition. This review summarizes our current understanding of the molecular defects present in patients with an MPN, and the effects of mutations targeting Janus kinase 2 (JAK2)-mediated intracellular signaling on DNA damage and on the elimination of mutation-bearing cells by programmed cell death. Moreover, we discuss findings that suggest that the acquisition of disease-initiating mutations in hematopoietic stem cells of some MPN patients may be the consequence of an inherent genomic instability that was not previously appreciated.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
Instabilidade Genômica
/
Janus Quinase 2
/
Transtornos Mieloproliferativos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article