Scandium-44: benefits of a long-lived PET radionuclide available from the (44)Ti/(44)Sc generator system.
Curr Radiopharm
; 5(3): 187-201, 2012 Jul.
Article
em En
| MEDLINE
| ID: mdl-22642388
ABSTRACT
(44)Ti/(44)Sc radionuclide generators are of interest for molecular imaging. The 3.97 hours half-life of (44)Sc and its high positron branching of 94.27% may stimulate the application of (44)Sc-labeled PET radiopharmaceuticals. This review describes the current status of (44)Ti production, (44)Ti/(44)Sc radionuclide generator development, post-processing of generator eluates towards medical application, identification of ligands adequate to Sc(III) co-ordination chemistry, proof-of-principle labeling of (44)Sc-DOTA-octreotides, investigation of in vitro and in vivo parameters, and initial applications for molecular imaging - both in small animals and humans.
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Base de dados:
MEDLINE
Assunto principal:
Radioisótopos
/
Geradores de Radionuclídeos
/
Escândio
/
Titânio
/
Compostos Radiofarmacêuticos
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Tomografia por Emissão de Pósitrons
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article