pHH3 and survivin are co-expressed in high-risk endometrial cancer and are prognostic relevant.
Br J Cancer
; 107(1): 84-90, 2012 Jun 26.
Article
em En
| MEDLINE
| ID: mdl-22644303
ABSTRACT
BACKGROUND:
Phosphohistone-H3 (pHH3) is a promising reliable mitotic count biomarker. Our purpose was to study the relationship between the novel proliferation marker pHH3 and the established anti-apoptotic marker survivin and consider their prognostic relevance in endometrial cancer.METHODS:
A total of 106 patients with endometrial cancer (type I/endometrioid, n=81; type II carcinomas, n=18) and simple hyperplasia without atypia (n=7) were investigated. pHH3 and survivin expression were assessed using immunohistochemistry from paraffin-embedded tissue blocks.RESULTS:
A strong positive correlation was observed between pHH3 and survivin expression (P<0.0001). Patients with high-grade tumours and patients with type II carcinomas expressed significantly more pHH3 and survivin than low grade and endometrioid tumours (P<0.0001, P<0.0001, P<0.0001, and P<0.0001, respectively). In univariate survival analysis, overexpression of pHH3 and survivin were associated with increased recurrence and mortality (P<0.0001, P<0.0001, P<0.0001, and P<0.0001, respectively), in the multivariable Cox regression analyses both pHH3 and survivin could be identified as independent parameters for overall survival (P=0.004, and P=0.023, respectively).CONCLUSION:
In endometrial cancer, pHH3 and survivin were strongly positive correlated and were both associated with type II and high-grade tumours. Increasing expression levels of pHH3 and survivin were associated with adverse prognostic factors.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Histonas
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Biomarcadores Tumorais
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Neoplasias do Endométrio
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Proteínas Inibidoras de Apoptose
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article