Paraoxonase 1 (PON1) as a marker of short term death in breast cancer recurrence.
Clin Biochem
; 45(16-17): 1503-5, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-22659076
ABSTRACT
OBJECTIVE:
To relate paraoxonase (PON1) activity to survival time and short term death in breast cancer recurrence. DESIGN ANDMETHODS:
PON1 activity was measured by its rate of hydrolysis of two different substrates, paraoxon (PON) and phenylacetate (ARE) in 50 patients with recurrence of breast cancer. Results were compared between patients surviving more than one year after the analysis (22) and those who died within one year (28).RESULTS:
In a logistic regression analysis, ARE was negatively associated with early death (OR=0.10 [0.02-0.58], p=0.0109). PON did not reach significance (OR=0.43 [0.17-1.11], p=0.0826). In a multiple logistic regression analysis model, ARE was independently associated with early death (OR=0.12 [0.02-0.98], p=0.0476), besides interval time between diagnosis and recurrence (OR=0.54 [0.27-1.07], p=0.0781) and undernutrition (OR=3.95 [0.81-19.19], p=0.0883).CONCLUSION:
Paraoxonase is a potential marker of survival in patients with breast cancer recurrence.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
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Biomarcadores Tumorais
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Carcinoma Ductal de Mama
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Arildialquilfosfatase
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Recidiva Local de Neoplasia
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article